| History: Individuals with thyroid cancer usually report a single, firm, nontender lump (nodule) at the base of the neck. If the tumor is pressing on other structures in the neck, symptoms may include hoarseness or loss of voice from pressure on nerves in the vocal chord (larynx) and difficulty swallowing or breathing due to pressure on the throat (esophagus) or wind pipe (trachea), respectively. If the tumor has spread (metastasized), the individual may report respiratory difficulties, cough, blood in the sputum (hemoptysis), chest pain, and musculoskeletal problems such as bone pain. Physical exam: Manipulation with the fingers (palpation) may reveal a single, firm, nontender, symmetric, or asymmetric mass (nodule) at the base of the neck. Occasionally, the thyroid will appear perfectly normal despite the presence of a cancerous growth. More advanced thyroid tumors may be larger, or they may have many nodules (multinodular). Often, they are firmly attached to adjacent structures in the neck. Enlarged lymph nodes may be present if the tumor is advanced. Metastasis of the tumor may result in weight loss. Tests: Thyroid nodules can be visualized through the use of a radioisotope (131I or 99Tcm pertechnetate). After the individual has swallowed (or been injected with) the radioisotope, images of the thyroid are captured on a specialized (gamma) camera. Only the thyroid tissue takes up the radioisotope. The results of this test allow determination of the size of the tumor and whether it has spread to other parts of the body. Other tests may include x-ray, CT and MRI imaging scans, high-frequency sound waves (ultrasound) to visualize the tumor, and measurement of thyroid hormones (calcitonin and thyroxin) in response to stimulation of the thyroid gland (thyroid function tests). However, a definitive diagnosis for thyroid cancer can only be made by obtaining a tissue sample (biopsy) from the nodule. Biopsies are obtained by aspirating cells through a needle inserted into the suspicious mass (fine needle aspiration biopsy, or FNAB). Biopsy tissue is then used to determine if the nodule is cancerous. |
Source: Medical Disability Advisor