History: Individuals with preeclampsia may report edema of the hands, face, and ankles, weight gain in excess of 2 pounds (1 kg) per week, or particularly sudden weight gain over 1 to 2 days. Other symptoms may include severe headache, rapid heartbeat (tachycardia), dizziness, nausea, ringing or buzzing in the ears, double or blurred vision, irritability, drowsiness, vomiting, abdominal pain, and decrease in urinary output.
Eclampsia includes symptoms of mild preeclampsia in 25% of cases prior to the occurrence of seizures; however, eclampsia may occur without hypertension and proteinuria. Hypertension was reported to be absent in 16% of cases studied in the US (Ross). Women with severe preeclampsia are more likely to progress to seizures (Ross). Before the onset of a seizure, the woman may experience severe headache, confusion, blurred vision, or upper abdominal pain. The seizures consist of violent, rhythmic, jerking movements of the limbs. Breathing may be difficult due to the constriction of the muscles of the voice box (larynx). Coma may follow. Physical exam: An initial exam includes blood pressure measurement, evaluation of the pregnancy, and a complete physical exam to evaluate possible organ system dysfunction if preeclampsia is suspected. Monitoring of blood pressure, edema, and proteinuria is then done at each subsequent physician visit. Hypertension is the most important standard for judging preeclampsia. Mild preeclampsia involves borderline hypertension (140/90). Any significant blood pressure increase during the second trimester is a warning signal.
Abdominal pain in severe eclampsia may be caused by an enlarged liver, which may be detected by pressing on the upper right abdomen with the hand (palpation). Examination of the eyes (ophthalmic exam) may show the arteries of the eyes in spasm, causing the blurred vision. Women may show neurological signs such as increased reflexes (hyperreflexia), loss of vision, confusion, and sometimes unconsciousness or coma if eclampsia has already developed. Tests: No single test can diagnose preeclampsia. Urinalysis may reveal proteinuria. If preeclampsia is suspected because of elevated blood pressure, a complete blood count with peripheral smear is done, as well as a blood chemistry profile, including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, lactate dehydrogenase (LDH), indirect bilirubin, and uric acid. In severe preeclampsia, blood tests may reveal elevated levels of hemoglobin and hematocrit indicating increased blood viscosity and hemoconcentration. Coagulation tests (prothrombin time [PT], partial thromboplastin time [PTT], and fibrinogen) may be abnormal, and platelet counts may be decreased. Elevated uric acid and serum creatinine indicate kidney dysfunction. Liver function tests may be abnormal; alkaline phosphatase may increase 2 to 3 times the normal level due to liver injury. Neurological studies that may be useful include brain computed tomography (CT) or magnetic resonance imaging (MRI) with transcranial Doppler to rule out intracranial bleeding and identify central nervous system lesions that are sometimes responsible for seizures. An ultrasound scan of the abdomen can be done to eliminate other etiologies of abdominal pain and to evaluate the status of the pregnancy.
No test or group of symptoms reliably predicts which woman will develop eclampsia other than having a prior diagnosis of preeclampsia. |