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Lupus Erythematosus, Systemic

Differential Diagnoses

Autoimmune thyroid disease
Cytomegalovirus
Epstein-Barr virus
Fibromyalgia syndrome
Hepatitis
Human immunodeficiency virus (HIV)
Lyme borreliosis
Lymphomas and other cancers
Other connective tissue diseases (e.g., scleroderma, rheumatoid arthritis)
Subacute bacterial endocarditis
Syphilis
Tuberculosis
Vasculitis

Specialists

Cardiovascular Internist
Clinical Psychologist
Dermatologist
Nephrologist
Neurologist
Psychiatrist
Rheumatologist

Comorbid Conditions

Hepatitis
Kidney disease
Multiple sclerosis

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Factors Influencing Duration

Length of disability depends on the severity of symptoms and the organs involved. Treatment, particularly prolonged corticosteroid therapy, may produce side effects that can also cause disability.

Medical Codes

	ICD-9-CM:
	710.0 -	Diffuse Diseases of Connective Tissue, Lupus Erythematosus, Systemic; Disseminated Lupus Erythematosus; Libman-Sacks Disease
	710.9 -	Diffuse Diseases of Connective Tissue, Unspecified

The prognosis for individuals with SLE has improved over the past two decades. Females with disease onset after age 60 have the most favorable prognosis. Children with SLE have the least favorable prognosis. However, because the course of lupus is unpredictable, the prognosis may vary. About half of all individuals with lupus experience kidney involvement, which can lead to life-threatening conditions. The 10-year survival rate is now 70% to 90% (Greenspun). Factors aiding this improved prognosis include a more accurate diagnosis, faster and more effective treatment, availability of dialysis for treatment of kidney failure, and more availability of antibiotics effective in treating infectious complications. In most individuals, the illness pursues a mild, ongoing (chronic) course, occasionally interrupted by relapses of disease activity. For many, the disease may affect only a few organs.

Source: Medical Disability Advisor

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