Sedentary Work Exerting up to 10 pounds (4.5 kg) of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull, or otherwise move objects, including the human body. Sedentary work involves sitting most of the time, but may involve walking or standing for brief periods of time. Jobs are sedentary if walking and standing are required only occasionally and other sedentary criteria are met.

Light Work Exerting up to 20 pounds (9.1 kg) of force occasionally and/or up to 10 pounds (4.5 kg) of force frequently, and/or negligible amount of force constantly to move objects. Physical demand requirements are in excess of those for Sedentary Work. Light Work usually requires walking or standing to a significant degree. However, if the use of the arm and/or leg controls requires exertion of forces greater than that for Sedentary Work and the worker sits most the time, the job is rated Light Work.

Medium Work Exerting up to 50 (22.7 kg) pounds of force occasionally, and/or up to 25 pounds (11.3 kg) of force frequently, and/or up to 10 pounds (4.5 kg) of forces constantly to move objects.

Heavy Work Exerting up to 100 pounds (45.4 kg) of force occasionally, and/or up to 50 pounds (22.7 kg) of force frequently, and/or in excess of 20 pounds (9.1 kg) of force constantly to move objects.

Very Heavy Work Exerting in excess of 100 pounds (45.4 kg) of force occasionally, and/or in excess of 50 pounds (22.7 kg) of force frequently, and/or in excess of 20 pounds (9.1 kg) of force constantly to move objects.

Job Classification

In most duration tables, five job classifications are displayed. These job classifications are based on the amount of physical effort required to perform the work. The classifications correspond to the Strength Factor classifications described in the United States Department of Labor's Dictionary of Occupational Titles. The following definitions are quoted directly from that publication.

Sedentary Work Exerting up to 10 pounds (4.5 kg) of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull, or otherwise move objects, including the human body. Sedentary work involves sitting most of the time, but may involve walking or standing for brief periods of time. Jobs are sedentary if walking and standing are required only occasionally and other sedentary criteria are met.

Light Work Exerting up to 20 pounds (9.1 kg) of force occasionally and/or up to 10 pounds (4.5 kg) of force frequently, and/or negligible amount of force constantly to move objects. Physical demand requirements are in excess of those for Sedentary Work. Light Work usually requires walking or standing to a significant degree. However, if the use of the arm and/or leg controls requires exertion of forces greater than that for Sedentary Work and the worker sits most the time, the job is rated Light Work.

Medium Work Exerting up to 50 (22.7 kg) pounds of force occasionally, and/or up to 25 pounds (11.3 kg) of force frequently, and/or up to 10 pounds (4.5 kg) of forces constantly to move objects.

Heavy Work Exerting up to 100 pounds (45.4 kg) of force occasionally, and/or up to 50 pounds (22.7 kg) of force frequently, and/or in excess of 20 pounds (9.1 kg) of force constantly to move objects.

Very Heavy Work Exerting in excess of 100 pounds (45.4 kg) of force occasionally, and/or in excess of 50 pounds (22.7 kg) of force frequently, and/or in excess of 20 pounds (9.1 kg) of force constantly to move objects.

Multiple Myeloma


Related Terms

  • Multiple Myelomatosis
  • Plasma Cell Myeloma

Differential Diagnosis

Specialists

  • Cardiologist, Cardiovascular Physician
  • General Surgeon
  • Hematologist
  • Nephrologist
  • Oncologist
  • Orthopedic (Orthopaedic) Surgeon
  • Radiology Oncologist

Comorbid Conditions

  • Blood diseases
  • Diabetes
  • Immune disorders
  • Systemic infection

Factors Influencing Duration

Length of disability is determined by the severity of symptoms, stage of disease, advanced age, complications of the disease, and response to treatment.

Medical Codes

ICD-9-CM:
203.00 - Multiple Myeloma without Mention of Having Achieved Remission; Failed Remission
203.01 - Multiple Myeloma; Kahlers Disease, Myelomatosis; in Remission
203.02 - Multiple myeloma, in relapse

Overview

Multiple myeloma is an aggressive, cancerous (malignant) condition characterized by the overproduction of plasma cells in bone marrow, which cluster to form plasma cell tumors (marrow plasmacytomas). Plasma cells and antibody (immunoglobulin) production are important components of the body's immune system. Normal plasma cells are a type of white blood cell (mature B lymphocytes, or B cells) that respond to an invading organism (viral or bacterial) by producing antibodies, also known as immunoglobulins, against it. The types of immunoglobulin include IgE, IgG, IgM, IgA, and IgD. Each immunoglobulin molecule typically consists of two heavy chains and two light chains of proteins (polypeptides). In multiple myeloma, the abnormal plasma cells overproduce immunoglobulin G (IgG), immunoglobulin A (IgA), and/or light chains (portions of immunoglobulin). As certain types of immunoglobulin (IgG, IgA) are overproduced, other types are underproduced, which may impair immune function. In some cases of myeloma, an abnormal light chain called Bence Jones protein is precipitated out into the urine and serves as a diagnostic indication of myeloma.

Since healthy plasma cells are known to have a limited ability to divide and multiply, it has not been clearly understood how tumor plasma cells overproduce in myeloma. However, studies have shown there is a unique type of immature B lymphocyte (B cell) commonly found in myeloma that divides rapidly. Although normal B cells mature into functional plasma cells, these unique B cells may behave as tumor stem cells (malignant B cells) that overproduce the new myeloma cells and eventually form marrow plasmacytomas. Plasmacytomas are typically found in the bones of individuals with multiple myeloma and can occasionally be found in other organs, particularly in the lungs.

Four conditions typically develop as multiple myeloma progresses: anemia, problems with kidney function (renal damage), frequent bacterial infections, and bone loss. As healthy bone marrow is replaced by malignant plasma cells, there is reduced production of normally functioning red blood cells, which can result in anemia. Casts of discarded cells form in the tiny tubules of the kidneys and impair kidney function. Recurrent infection is also typical as the immune function becomes compromised by lack of necessary immunoglobulins and functioning white blood cells. Expansion of plasma cell tumors within the bone destroys bone tissue and can result in osteoporosis that can cause spontaneous fractures and spinal cord compression. Bone lesions (osteolytic lesions) may also develop because of a factor (osteoclast-activating factor) that is released by the myeloma cells. Calcium is released into the bloodstream, reducing bone stores of calcium while increasing the level of calcium circulating in the blood (hypercalcemia). This circulating calcium is not able to be utilized by the body, and its presence is another indication of the disease.

Incidence and Prevalence: Multiple myeloma occurs most often in older individuals with peak incidence at age 69. It is rare before the age of 40. The incidence of multiple myeloma is 4 in 100,000 individuals, slightly more in males than in females. The incidence in blacks is twice that in whites.

Source: Medical Disability Advisor






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